Wardija Hill, limits of St Paul's Bay will be closed to traffic for five days starting at 8am on Monday 18 July, Transport Malta has said.
Maintenance works will go on throughout the week with the road expected to reopen to traffic on Friday 22 July at noon.
Motorists have been advised to follow road signs and proceed with caution.
Transport Malta has also warned motorists that it will be constructing a centre strip at Triq il-Mini ta' Hompesch in Żabbar starting tonight at 1am. No road closure will take place, but motorists should drive with caution.