Tottenham Hotspur suffered a fresh blow to their Champions League hopes on Monday when Moussa Sissoko appeared to be ruled out of the first leg of their semi-final against Ajax.

The midfielder, one of Tottenham's outstanding players this season, suffered a groin injury in the return leg of the quarter-final tie at Manchester City and Spurs manager Mauricio Pochettino believes he will not be fit for another two weeks.

That would rule Sissoko out of the north London club's home leg against Dutch giants Ajax on April 30, with Tottenham already missing South Korea star Son Heung-min through suspension.

Son has been a key man for Spurs while England captain Harry Kane has been sidelined with an ankle injury.

"Moussa Sissoko is not going to be fit, maybe for the next two weeks, we hope he can recover before but I am not so optimistic," Pochettino said ahead of Tuesday's Premier League match at home to Brighton.

"Harry Winks we don't know because it is a problem that is one day very good, next day not very good, it is about assessing each day.

"We hope he will be available for Tuesday but we are not sure."

There are also doubts over the fitness of France goalkeeper Hugo Lloris, with Pochettino saying: "Lloris I hope yes, we are going to assess, we have a training session and we hope it is not a big issue, we hope he is going to be available."