Six Italian nationals and a Maltese man were arrested on drug-related charges shortly after disembarking from the Sicily catamaran.
The men, aged between 23 and 51, were netted following inspections carried out on the vehicles, shortly after they disembarked in Malta.
One of the cars, which was stopped in Birkirkara, yielded 20 kilos of suspected cannabis, which was spread out in 34 parcels, the police said in a statement.
The seven are being detained by the police and could possibly be arraigned in the coming days.
The operation was carried out by the police drug squad with the assistance of the customs enforcement unit.