Manchester City eased to a 16th consecutive Premier League win with a 4-1 rout of Tottenham.
Mauricio Pochettino's side would have hoped to have provide a stern test of City's magnificent form but they were powerless to resist the attacking verve of Pep Guardiola's side.
The opening goal was a horror show for Spurs, with Ilkay Gundogan left unmarked to head in Leroy Sane's corner.
Kevin De Bruyne drilled in a powerful second in the 70th minute and City could afford for Gabriel Jesus to miss a penalty before Raheem Sterling netted a brace.
A very late strike from Christian Eriksen was no consolation for Spurs.
Marko Arnautovic scored for West Ham to deepen former club Stoke's woes.
The pressure on Potters boss Mark Hughes will only intensify after a 3-0 home loss made it five defeats from six games and left them one point above the relegation zone.
By contrast, the Hammers are picking up nicely under David Moyes and this result saw them leapfrog their opponents and climb up to 15th.
After the game was delayed for an hour by a power cut, Mark Noble netted a 19th-minute penalty and Arnautovic, who had been booed throughout by the Stoke fans following his summer departure, celebrated gleefully after making it two in the 75th minute.
The Potters probably thought it could not get any worse but their porous defence was pierced again by Diafra Sakho.
Christian Benteke secured some redemption as Crystal Palace climbed out of the relegation zone with a 3-0 win at Leicester.
A week after defying manager Roy Hodgson's orders to take - and miss - a penalty, Benteke netted the opener in the 19th minute before Wilfried Zaha doubled the advantage prior to half time.
Things got worse for Leicester when birthday boy Wilfried Ndidi was shown a second yellow card for a dive and Bakary Sako scored an injury-time third on the break.
Huddersfield ended their away drought in style, beating Watford 4-1 in a game where referee Michael Oliver took centre stage.
The Terriers had not scored an away goal since the opening day of the season but Elias Kachunga, who was later carried off after suffering an apparently serious injury, gave them the lead only six minutes in.
Aaron Mooy doubled their advantage in the 23rd minute and their grip on the game tightened when Watford striker Troy Deeney was sent off for a dangerous tackle.
The game appeared over when Laurent Depoitre made it 3-0 five minutes after half-time but Huddersfield were controversially reduced to 10 men when Jonathan Hogg was shown a second yellow just past the hour mark.
Abdoulaye Doucoure pulled one back shortly afterwards but that was where Watford's comeback ended and Mooy's 89th-minute penalty gave Huddersfield the final word.
Arsenal and Chelsea were 1-0 winners over Newcastle and Southampton, respectively.
Mesut Ozil's brilliant 23rd-minute volley settled matters at the Emirates Stadium, while Chelsea moved level on points with Manchester United in second thanks to Marcos Alonso's free-kick in first-half stoppage time.
A missed penalty by Glenn Murray was the key moment of a goalless draw between Brighton and Burnley.
Murray was deemed to have been felled by James Tarkowski in the 36th minute but he sent the resulting spot-kick well over the bar.