Actor Brad Pitt has said he is "very saddened" after his wife Angelina Jolie filed for divorce.
The Hollywood couple, known collectively as Brangelina, married in 2014 after 10 years together.
Robert Offer, Jolie's lawyer, said the actress had filed for the dissolution of the marriage "for the health of the family".
In a statement to People magazine, Pitt said: "I am very saddened by this, but what matters most now is the well-being of our kids.
"I kindly ask the press to give them the space they deserve during this challenging time."
I am very saddened by this, but what matters most now is the well-being of our kids
Jolie filed for divorce on Monday citing irreconcilable differences, according to legal documents filed with the Los Angeles Superior Court.
The actress has asked for physical custody of the couple's six children - Maddox, Pax, Zahara, Shiloh, and twins Knox and Vivienne.
She also filed for Pitt to be granted child visitation rights and to share legal custody of the children.
Jolie is being represented by divorce lawyer Laura Wasser, who helped in her divorce from Billy Bob Thornton and has represented Johnny Depp in his divorce from Amber Heard.
Pitt, 52, and Jolie, 41, first met when they played married spies in the film Mr And Mrs Smith, when Pitt was still married to Friends star Jennifer Aniston.
The couple married in private at their chateau in France in 2014.
They had waited for gay marriage to become legal, with Pitt telling Esquire magazine in 2006: "Angie and I will consider tying the knot when everyone else in the country who wants to be married is legally able to."
Their ceremony included all their children, including adopted offspring Maddox, Pax and Zahara and their daughter Shiloh and twins Knox and Vivienne.
Jolie's Atelier Versace gown featured dozens of designs from her children's drawings sewn into the dress and veil and the children served as ring bearers and threw flower petals.
Jolie was previously married to Thornton and British actor Jonny Lee Miller.
Since Mr And Mrs Smith, the couple have appeared on screen together in By The Sea, a film written and directed by Jolie and produced by Pitt, in which they played a glamorous couple whose marriage is in crisis.
Before they began filming, Jolie told the Radio Times: "It feels a little daunting. We haven't worked together for 10 years. But all of the reasons why people say we should be scared of it, we feel that's exactly why we have to do this - because we can. So we're going to go boldly."
She added of Pitt: "He's a pretty strong actor. It's going to be interesting. He's a really great artist, such an interesting artist, and of course he's the man I love, so I think we're going to have a great time."
In May 2013 Jolie had a preventative double mastectomy after tests showed that she carries the BRCA1 cancer gene, and she later told US TV show Today: "I knew through the surgeries that he (Pitt) was on my side and that this wasn't something where I was going to feel less of a woman, because my husband wasn't going to let that happen.
"To face these issues together and speak about them and talk about what it is to be human, I think can be a beautiful thing."
Pitt's long-time friend, actor George Clooney, said the news was "a sad story" and "unfortunate for a family".
Clooney, 55, looked taken aback by the news when asked about it by CNN during an event at the United Nations.
CNN's Richard Roth asked the actor what he thought of the news at the end of an interview.
A video shows Clooney saying: "What happened?", followed by Roth explaining that Jolie had filed for divorce.
"I didn't know that. Wow," Clooney responded, adding: "I feel very sorry then. That's a sad story and unfortunate for a family. It's an unfortunate story about a family. I feel very sorry to hear that."
He added: "This is the first I've heard of it."