Caffe Moak Luxol set out on the road to defend their title with a straightforward win over Floriana.
Hibs and PAVI Depiro recorded good victories over Gżira Athleta and Starlites Sports Experience respectively.
Luxol were untroubled by newcomers Floriana who had several new players but still found it difficult to obtain points.
Luxol had victory wrapped up by the interval, 40-9, and went on to win 69-13.
Depiro produced a strong finish to ease past the young Starlites.
After a balanced first quarter, Depiro upped their tempo to change ends 35-23 ahead.
Depiro stayed in control after the interval before making a final push to cruise to a 69-34 win.
More was expected from Gżira against Hibs who delivered an early warning of their title intentions.
Gżira only lasted the pace for the first five minutes as Hibs, led by pivot Josephine Grima and forward Christine Grima, took control.
Hibs opened a 26-point lead, 41-15, by half-time. With Gżira’s reaction failing to materialise, Hibs ran out 67-41 winners.
Next fixtures
MSV Life League: Saturday – 14.45 Depiro vs Gżira. Sunday – 11.15 Floriana vs Starlites; 14.45 Hibs vs Luxol.