Even before a ball has been kicked at the World Cup in South Africa, several of the game's biggest stars have been struck down by injury.
Here, Press Association Sport's Jim van Wijk takes a look at some of the men who will have to sit and watch the biggest tournament on the planet from the sidelines - and a couple who face a nervous wait to see if they could feature.
DAVID BECKHAM (England, Achilles)
The 34-year-old former national-team skipper was all set to become the first England player to appear at four World Cups having forced himself back into Fabio Capello's plans, when disaster struck during AC Milan's 1-0 win over Chievo as Beckham broke down with a ruptured Achilles tendon.
RIO FERDINAND (England, knee)
After being set to follow in the footsteps of fellow former West Ham defender Bobby Moore, Manchester United centre-half and England captain Ferdinand did make it out to South Africa, but in the closing moments of the squad's first training session, suffered a knee injury during a challenge with Emile Heskey and will take no part in the World Cup.
MICHAEL BALLACK (Germany, ankle)
Germany captain Ballack hobbled off at Wembley following a challenge by Portsmouth's Kevin-Prince Boateng during the FA Cup final, and his worst fears were confirmed when scans revealed ligament damage, denying the 33-year-old Chelsea midfielder the opportunity of a third World Cup appearance.
MICHAEL ESSIEN (Ghana, knee)
Essien had not played for Chelsea since December because of a knee problem, and so looked doubtful to be involved in the Black Stars' World Cup campaign. Essien's absence is a major blow to the Africans' hopes of progressing from a group which also includes Germany, Australia and Serbia.
NANI (Portugal, collar bone)
The forward, who began to come to the fore for Manchester United during the domestic season, damaged his collar bone in training and was ruled out of the tournament. Nani sparkled in his first season at Old Trafford without compatriot Cristiano Ronaldo and was expected to sparkle alongside the Real Madrid forward in South Africa. His absence will weaken Portugal's attacking options.
JOHN OBI MIKEL (Nigeria, knee)
The third of Chelsea's World Cup crocks also suffered a knee problem, and underwent minor surgery in May. Although he joined up with the squad in South Africa, the 23-year-old decided he would not be fit enough to take part, and pulled out of the tournament.
DIDIER DROGBA (Ivory Coast, broken arm)
Ivory Coast boss Sven-Goran Eriksson will be praying Drogba can fend off Chelsea's injury jinx after suffering a broken bone in his arm during a friendly against Japan - leaving the striker in a race against time to be fit to play in South Africa, when Ivory Coast will face Brazil, Portugal and North Korea in the 'Group of Death'.
ARJEN ROBBEN (Holland, hamstring)
Winger Robben, the star of Bayern Munich's run to the Champions League final, has vowed to do everything possible to play at the World Cup, despite suffering a torn hamstring in Saturday's 6-1 friendly win over Hungary. The player himself admits the injury would normally take up to six weeks to heal, so his participation still looks in doubt.