Works to revamp Castille Square will start on Monday, Transport Malta said.
It said in a statement the roundabout and central strips will be removed and works on water, electricity and telecommunication services will also be carried out.
The authority said traffic will not be affected, however, since space will be limited, vehicles will not be allowed to stop to drop or pick up passengers.
Tourist coaches will operate from Floriana Mall.
Motorists should proceed with caution and follow signage.
Enforcement officers will be on site.
Works on this €1.6 million project are expected to be completed by October, in time for the CHOGM summit set for November.
A number of trees were removed from the site last week, while preparations were made to remove the monument to George Borg Olivier, which will later be put in the square once more.