A 30-year-old woman who lives in St Julian's was seriously injured when she was hit by a car in Triq San Ġorġ.
She was taken to Mater Dei Hospital by ambulance.
The woman, a Russian national, was hit by a Peugeot 607 driven by a 41-year-old man from Marsascala at 3.30am.
An inquiry is being held.