She died peacefully at home, aged 98.
“The loss is a loss for the entire country. She was a woman of dignity who served for a long time with her husband in the highest levels of the country,” the Nationalist Party said.
Read: Maria Tabone - 90 years young
The party noted that she had supported him through his medical and political career, culminating in his term as president which started in 1989.
She married him at the height of the Second World War, bearing nine children, eight of whom survived.
Watch: Ċensu and Maria Tabone – 70 years married today
Ċensu and Maria Tabone in 2012.President Marie Louise Coleiro Preca expressed her condolences on her behalf and on behalf of the Maltese people.