The Xarabank programme raised a record €915,772 for Puttinu Cares in a special programme held yesterday.
"No thank you is good enough" presenter Peppi Azzoprdi said amid applause and some tears of joy.
President Marie-Louise Coleiro Preca said she was proud of the generosity of the Maltese people.
The programme has become a regular feature of Good Friday, raising funds for the cancer patient care foundation and also highlighting the problems which patients - particularly young patients - and their families endure.
Puttinu needs the funds to pay for the overseas care of Maltese cancer patients. €2,599,015 have been raised by Xarabank for Puttinu in the past two years through various initiatives.