A 42-year-old Italian man was seriously injured early on Sunday morning in a crash involving two cars in St Joseph High Road, Ħamrun.
The police said the crash took place at 4.45am and involved a Peugeot 106 in which the victim was a passenger, and a VW Passat.
The driver of the Peugeot, a 36-year-old Italian, was also hospitalised but his injuries are not serious.
The Passat was being driven by a 34-year-old man from Sta Venera.