The hospital (colloquially known as Boffa Hospital) was originally built in 1922 for the convalescence of sailors. This hospital was damaged during aerial bombardment during World War II and was partly reconstructed after the war as it was originally.

The hospital has a symmetrical façade consisting of a central colonnaded portico with an identical terrace at first floor. The wings are plain having five windows at both ground and first floor on each side. Built in the shape of the letter "H" with an additional block erected later, the building is practically surrounded with a veranda at ground floor and a terrace at first floor, all columned and having wrought iron railings.

On the left side are a series of utility buildings, some of which are not as old as the hospital.

Within the hospital are a number of inscriptions and Second World War relics, including a piece of sculpture from Parliament House in London. Of note are the stained glass windows in the chapel.

Mepa scheduled King George V, Seamans Memorial Hospital as a Grade 2 national monument as per Government Notice no. 628/08 in the Government Gazette dated July 21, 2008.