Anastasia Myskina's preparations for the defence of her French Open title suffered another setback on Wednesday as she lost to 15-year-old Czech Nicole Vaidisova in the Family Circle Cup second round.

World number one Lindsay Davenport, defending champion Venus Williams and former number one Justine Henin-Hardenne advanced but Myskina's poor form continued as she suffered her second early exit in as many weeks losing 6-3 5-7 6-4 to the teenager.

Top seed Davenport cruised past world number 129 Marie-Eve Pelletier of Canada 6-2 6-2 to set up a clash with another qualifier, Viktoriya Kutuzova of Ukraine. In the night match, Venus Williams opened the defence of her title with a 7-6 6-2 victory over Czech Denisa Chladkova.

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