The government pharmacy at Mosta will be operating for the last time today.
The Health Division said all patients will instead pick up the medicines they are entitled to for free from their chosen pharmacy as part of the Pharmacy of Your Choice scheme.
The division said the residents of Mosta, Naxxar, Għargħur, St Paul's Bay, Burmarrad, Mġarr and Mellieħa who have not yet registered for the scheme, should do so with their chosen pharmacy immediately.
The roll-out of the scheme to other areas has been put on hold because of lack of staff at the government's central pharmacy.