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Oivend Xuereb, 30, was reported missing on Thursday, the police have said.
Mr Xuereb, who was last seen in Baħar iċ-Ċagħaq wearing a dark top and light-coloured trousers, was following a Caritas residential drug rehabilitation programme and went missing while in its custody.
Whoever has any information about his whereabouts can call on 119/2122 4001 or visit the nearest police station.