Americans who included Mega Million tickets on their holiday shopping lists have a shot at winning more than $300 million in Tuesday's drawing, the largest Christmas Day jackpot in the history of the multi-state lottery.

The lucky numbers are 2, 8, 42, 43, 50 and Mega ball 6.

The grand prize has grown to $321 million after a nine-week spell without a winner. Combined with a $294 million Powerball jackpot up for grabs on Wednesday, the holiday week could deliver prizes worth more than $600 million.

No winning tickets were immediately announced.

The televised Mega Millions drawing, only the fifth ever on Christmas Day, was held at 11 pm Eastern time (0400 GMT Wednesday), with a machine selecting six numbered balls, including the "Mega ball."

There have been no Christmas Day grand prize winners so far, Mega Millions said.

The pot, with a value calculated on the basis of a 29-year payout, is drawn from sales in 44 states, the District of Columbia and the US Virgin Islands.

The immediate cash value of the prize, which winners can opt to take, is $193.7 million, Mega Millions said.

While the odds of hitting the jackpot are one in 302.6 million, the chances of turning a $2 Mega Millions ticket into a winner of any kind, including a $2 prize simply for matching the "Mega ball," are one in 24.

The biggest-ever Mega Millions prize, $1.537 billion, went to the holder of a single ticket in a drawing on October 23. The ticket was sold in South Carolina to someone who has yet to come forward, Mega Millions said.

That winning ticket fell just short of the US record, a $1.586 billion Powerball grand prize in 2016.