Germany had goalkeeper Ron-Robert Zieler sent off after half an hour as they crashed to a 3-1 friendly defeat to Argentina in Frankfurt.
Zieler was dismissed for a foul on Jose Sosa and, although replacement Marc ter Stegen saved Lionel Messi's resulting penalty, the visitors did not take long to seize the lead.
Sami Khedira put through an own goal in first-half injury time to set Argentina on their way and further second-half goals from Messi and Angel di Maria sealed the win before Benedikt Howedes' late consolation.
Holland continued their poor form heading out of a disappointing Euro 2012 as they fell 4-2 at neighbours Belgium.
Luciano Narsingh and Klaas Jan Huntelaar had cancelled out Christian Benteke's early opener for the home side, but further goals from Dries Mertens, Romelu Lukaku and Jan Vertonghen gave the Belgians an excellent win.
There were no such concerns for Brazil, who beat Sweden 3-0 in Solna with the first from Leandro Damiao on 32 minutes and a brace in the final six minutes from Alexandre Pato.
England gained some measure of revenge for their Euro 2012 semi-final defeat to Italy with a 2-1 win in Bern.
Daniele De Rossi opened the scoring on 15 minutes for the Italians but Phil Jagielka hit a 28th-minute equaliser and Jermain Defoe blasted home a superb long-range winner 10 minutes from time.
Croatia were stunned 4-2 by Switzerland in Split, with Mario Gavranovic's double helping the Swiss to victory, while Russia were held 1-1 in Moscow by the Ivory Coast, Alan Dzagoev's opener cancelled out late by Mark Gradel.
France were held to a goalless draw by Uruguay in Le Havre, as were Serbia by the Republic of Ireland in Belgrade.
Konstantin Vassiljev's injury-time goal gave Estonia a 1-0 home win over disappointing Euro 2012 co-hosts Poland.
Jordan Rhodes needed just 29 minutes to net on his debut as Scotland came from behind to beat Australia 3-1 in Edinburgh, while Greece eased to an impressive 3-2 win over Norway in Oslo.
Two goals in four minutes before the break set Spain on course for a 2-1 win over Puerto Rico.
New Arsenal signing Santi Cazorla fired in the first from the edge of the area, and ex-Gunners captain Cesc Fabregas got the second moments later on the stroke of half-time.
Marc Cintron pulled one back for the hosts in the 65th minute.
Nelson Oliveira and Cristiano Ronaldo got the goals as Portugal beat 10-man Panama 2-0 at the Estádio do Algarve.
Oliveira beat two men before lashing the ball into the top corner on the half-hour mark and, after Gabriel Gomez was sent off early in the second half for a clash with Joao Moutinho, Ronaldo turned to fire home moments later.