Four players from Premier League clubs have been given a one-match ban for four yellow cards.
Valletta will be without Brazilian midfielder William Barbosa for their match against Tarxien Rainbows on Tuesday.
Hibs defender Ryan Camilleri will miss Wednesday's match against Sliema Wanderers while Mosta centre-half Ferdinando Apap has been ruled out of his side's clash with Birkirkara, also to be played next Wednesday.
Rabat Ajax midfielder Joseph Caruana will have to skip his side's Relegation Pool match against Floriana on Tuesday.