Updated 10.35am - Added video
The first two lanes of the Kappara Junction project opened to traffic on Tuesday evening, with the first vehicles escorted by police motorcycles.
Traffic heading from the Msida direction towards St Julian's can now use the newly-built flyover in the €23 million project, which will eventually be used by some 90,000 cars a day.
Watch: New section of Kappara junction to be laid this weekend
The 77-week project is still on time - no mean feat for a road project of this size - and is anticipated to cut traffic on the notorious stretch of road by half.
Workers will now be working on the section leading from the Regional Road to San Ġwann.