Champions Hibernians are widely tipped to pick up maximum points and tighten their grip on top spot when they take on struggling Pembroke who have lost their last three games.
The Paolites are on a roll after back-to-back victories over Tarxien and Valletta propelled them to the top of the standings.
Branko Nisevic, the Hibernians coach, is boosted by the return of Brazilian Denni who has completed a two-match ban.
Young goalkeeper Rudy Briffa is set to retain his place in goal after keeping a clean sheet in the last two games.
Winger Ariel Laudisi is doubtful for Pembroke.