Sections of Naxxar Road in Birkirkara will be closed because of works in connection with the National Flood Relief Project, Transport Malta said.
Closures start tomorrow and will take two months.
Buses will be diverted through Ganu Street and Valley Road, Balzan, depending on the phase in hand.
Transport Malta will be issuing updates and more information about traffic diversions and road closures during the course of implementation.
Motorists were advised to proceed with caution and to follow signage on site.