Arsenal’s Mesut Ozil avoids the challenge of Barry Bannan, of Crystal Palace, last weekend.

Arsenal, who suffered a humiliating Capital One (League) Cup quarter-final defeat by fourth-tier Bradford City last season, will again rotate their squad when Chelsea visit the Emirates in the last-16 today.

Manager Arsene Wenger has used the competition in recent years to blood youngsters and field fringe players and did so when a second-string side edged out West Bromwich Albion in a penalty shoot-out in the third round.

“I will rotate against Chelsea but play with a team that has a good chance to qualify as well. That will be the target,” Wenger told the club’s website (www.arsenal.com).

Arsenal have not won the trophy since 1993 when they beat Sheffield Wednesday. They lost to Chelsea in the 2007 final and to Birmingham City at the same stage four years later.

Adding spice to the tie is the Premier League positions of the two clubs, with Arsenal two points clear of their London rivals at the top of the table.

Wenger’s team have a tough sequence of games coming up that will test their credentials as title contenders.

Arsenal host third-placed Liverpool in the Premier League on Saturday and then, after travelling to Borussia Dortmund in the Champions League, they take on Manchester United at Old Trafford.

“You worry about fatigue a little bit but not too much. Sometimes when you play every three days you look tired and then in three days you are flying again. It goes a bit in cycles,” Wenger said.

There are four other all-Premier League clashes.

Manchester United, who came back from 2-1 down to beat Stoke City 3-2 on Saturday, should prove too strong for struggling Norwich City at Old Trafford tonight.

Tomorrow, Newcastle United entertain Manchester City and Tottenham Hotspur host Hull City again, three days after a 1-0 league victory for the Londoners at White Hart Lane.

Southampton also travel to Sunderland on November 6.

Championship leaders Burnley will fancy their chances of causing an upset when they host West Ham United today.

Burnley, who spent one season in the Premier League in 2009-10, have won eight and drawn one of their last nine league games and manager Sean Dyche said Saturday’s home victory over promotion rivals Queens Park Rangers was their best performance so far.

Two other second-tier sides welcome Premier League opposition.

Surprise 2011 winners Birmingham, who stunned Arsenal at Wembley with a late Obafemi Martins winner, entertain Stoke while Leicester City, who won the trophy in 1997 and 2000, take on Fulham.

Fourth round
Today: 20.45 Arsenal vs Chelsea; Birmingham vs Stoke; Burnley vs West Ham; Leicester vs Fulham; Man. United vs Norwich.
Tomorrow: 20.45 Newcastle vs Man. City; Tottenham vs Hull.
November 6: 20.45 Sunderland vs Southampton.