FA Cup holders Chelsea could face Premier League leaders Manchester United at Old Trafford in the quarter-finals if both win fifth-round ties.
United must beat Reading in their last-16 meeting tonight while Chelsea, who crushed Brentford 4-0 in a fourth-round replay yesterday, have to get past Championship team Middlesbrough who they meet at the Riverside on Feb. 27.
United last reached the FA Cup final in 2007 which they lost 1-0 to Chelsea at Wembley with Didier Drogba scoring the winner late in extra-time.
Manchester City, the 2011 winners, were drawn at home to second-tier Barnsley.
Yesterday’s last-eight draw created another potential all top-flight encounter with Everton hosting Wigan Athletic if David Moyes’s side can get past third-tier Oldham Athletic in a replay at Goodison Park.
Oldham scored a stoppage-time equaliser to hold Everton to a 2-2 draw on Saturday.
Blackburn Rovers were rewarded for a shock 1-0 fifth-round win at Arsenal with another trip to the capital, this time to face fellow Championship outfit Millwall, the 2004 finalists.
Quarter-finals draw
Oldham/Everton vs Wigan
Manchester City vs Barnsley
Manchester United/Reading vs Middlesbrough/Chelsea
Millwall vs Blackburn Rovers
Matches to be played weekend of March 9/10.