Rescuers combed through overturned cars and flattened buildings yesterday hunting for survivors after this Missouri town was struck by one of the strongest tornadoes ever recorded in the US.

A massive mile-wide funnel-cloud, with winds of up to 320 kilometres an hour, tore with devastating force through the town of Joplin late on Sunday, leaving 116 people dead and left hundreds more missing.

Joplin city manager Mark Rohr said early yesterday said there was an increasing sense of urgency, as rescuers scoured the town’s rubble and debris in hopes of finding more survivors.

“People’s lives are at stake,” Mr Rohr told a press conference.

“We are still in search and rescue mode, and will be for the foreseeable future,” he said, almost two full days since the disaster flattened much of the town of some 50,000 people.

The Joplin tornado is on course to be classified as the deadliest single twister to strike the United States since modern records began in 1950 - matching the toll in a tornado in Flint, Michigan in 1953 that also left 116 people dead.

More than 2,000 buildings –about a third of this town that borders the heartland states of Kansas and Oklahoma ­– were damaged or destroyed, when the twister came roaring through with just a 24-minute warning. Sunday’s massive twister cut a swath of destruction 6.4 kilometres long and more than a kilometre wide. Brandon Hicks, 26, was lucky enough to be on an out-of-town fishing trip when the twister struck, but came home to discover that his house, as well as one across the street belonging to his brother, was completely destroyed.

“We’re trying to get everything salvaged, before the next storm hits,” Mr Hicks said as he sorted through the ruins of his possessions, and forecasters warned more potent storms could be on the way, perhaps as early as Tuesday.

Some news reports said as many as 1,500 people were still unaccounted for, although there was hope that some might have found their way to homes of friends and relatives outside the immediate area.

On a hopeful note, 17 people were reported to have been pulled alive on Monday from under the debris and rubble following the tornado, although officials said they were able to confirm only seven rescued.

Desperate residents meanwhile phoned local radio stations seeking information about still-missing loved ones.

The town’s Facebook page has become an online kiosk for news about which nearby restaurants are offering free meals and where to find emergency shelter.

Residents were vowing to pull together in the aftermath of the calamity, saying they will eventually rebuild Joplin.

But the first order of business, they said, is to search for anyone trapped in the rubble and wreckage who might still be alive.

Churches and shelters lent their efforts to the rescue, sending legions of volunteers - assistance city officials said they were grateful for.

Joplin “has had a wonderful outpouring of support from volunteers coming into our community to affect that search and rescue,” Mr Rohr said yesterday.

Responders have encountered trying conditions, including heavy rain, and rescue operations had to be suspended on Monday after two men were struck by lightning, one of whom was seriously injured.

US President Barack Obama plans to tour the disaster scene on Sunday.