Broad sweeps of the human genome have exposed genetic mutations that boost the risk of the devastating yet baffling diseases of schizophrenia and bipolar disorder, according to two studies.

The independent studies, each conducted by a consortium of about 200 scientists, also found significant genetic overlap between the debilitating mental disorders.

Schizophrenia patients typically hear voices that are not real, tend toward paranoia and suffer from disorganised speech and thinking. The condition is thought to affect about one per cent of adults worldwide.

Previously known as manic depression, bipolar disorder is characterised by hard-to-control mood swings that veer back-and-forth between depression and euphoria, and afflicts a similar percentage of the population.

The biological profile of both conditions remain almost entirely unknown. Doctors seek to hold them in check with powerful drugs.

Scientists have long observed that each syndromes tends to run in families, suggesting a powerful inherited component.

But, early hopes of finding a single-gene culprit swiftly faded, giving way to the realisation that – to the extent DNA is at fault – blame is probably spread across dozens, maybe even hundreds of DNA variants. Genome-wide comparisons made possible by gains in computing power involve sweeps of tens of thousands of individual genetic codes from patients and otherwise healthy counterparts.

But so far only a handful of suspects have been found that, at best, account for about 30 per cent of the heritable component of schizophrenia.

Nailing down genetic drivers is made even harder by uncertainty as to whether schizophrenia and bipolar – defined by a varying constellation of symptoms – are single or multiple diseases.

In one of the largest gene sweeps so far, Pablo Gejman of the University of Chicago and colleagues worldwide started by reviewing 17 earlier efforts involving nearly 22,000 people, just under half of them schizophrenia patients.