Third qualifying round
| 1st leg | 2nd leg | Agg. | |
| Ermis Aradippou vs Young Boys | 0-1 | 0-2 | 0-3 |
| Chornomorets Odesa vs RNK Split | 0-2 | 0-0 | 0-2 |
| FC Krasnodar vs Diosgyor | 5-1 | 3-0 | 8-1 |
| Molde FK vs FC Zorya Luhansk | 1-1 | 1-2 | 2-3 |
| Slovan Liberec vs Astra Giurgiu | 0-3 | 2-3 | 2-6 |
| Esbjerg vs Ruch Chorzow* | 0-0 | 2-2 | 2-2 |
| Ironi Kiryat Shmona vs Dinamo Moscow | 1-1 | 1-2 | 2-3 |
| AIK vs FC Astana | 1-1 | 0-3 | 1-4 |
| Shakhtyor Soligorsk vs Zulte-Waregem | 5-2 | 2-2 | 7-4 |
| SKN St Polten vs PSV Eindhoven | 0-1 | 2-3 | 2-4 |
| Lech Poznan vs Stjarnan | 0-1 | 0-0 | 0-1 |
| Chikhura Sachkhere vs FK Neftchi | 0-0 | 2-3 | 2-3 |
| Rosenborg vs Karabukspor* | 0-0 | 1-1 | 1-1 |
| CFR Cluj vs Dinamo Minsk | 0-1 | 0-2 | 0-3 |
| Hajduk Split vs Shakhter Karagandy | 2-4 | 3-0 | 5-4 |
| Spartak Trnava vs St Johnstone | 2-1 | 1-1 | 3-2 |
| Atromitos vs FK Sarajevo | 2-1 | 1-3aet | 3-4 |
| Brondby IF vs Club Brugge | 0-3 | 0-2 | 0-5 |
| Viktoria Plzen vs Petrolul Ploiesti | 1-1 | 1-4 | 2-5 |
| Asteras Tripolis vs Mainz 05 | 0-1 | 3-1 | 3-2 |
| Torino vs Brommapojkarna | 3-0 | 4-0 | 7-0 |
| Olympique Lyon vs Mlada Boleslav | 4-1 | 2-1 | 6-2 |
| Hull City vs AS Trencin | 0-0 | 2-1 | 2-1 |
| FH Hafnarfjordur vs Elfsborg | 1-4 | 2-1 | 3-5 |
| Metalurg Skopje vs Omonia Nicosia | 0-3 | 0-1 | 0-4 |
| Aberdeen vs Real Sociedad | 0-2 | 2-3 | 2-5 |
| Rio Ave vs IFK Gothenburg | 1-0 | 0-0 | 1-0 |
| Zimbru Chisinau* vs SV Groedig | 2-1 | 0-1 | 2-2 |
| Rijeka vs Vikingur | 5-1 | 4-0 | 9-1 |