Anne Jackson, a Tony Award-nominated theatre actress who often appeared on stage with her husband, Eli Wallach, in comedies and classics, has died. She was 90.

Peter Wallach said his mother died at her home in Manhattan, New York, of natural causes.

Jackson and Wallach were a formidable duo on the stage, starring in a series of plays, including George Bernard Shaw’s Major Barbara in 1956 and a hugely successful run of Luv, directed by Mike Nichols, in the mid-1960s.

Their partnership was epic by Hollywood acting-couple standards. They played a married couple together as recently as 2003 in the NBC medical drama ER.