A total of 4,022 operations were performed at Mater Dei in November, up by 128 on November 2010.
3,489 (87%) operations were scheduled while the rest were emergencies.
Health Minister Joseph Cassar welcomed the statistics, saying that 40,511 operations were performed between January and November.
He said that government efforts to reduce waiting lists were bearing fruit. 32,764 operations were performed in the last full year of St Luke's Hospital.