Manchester United will come up against their former striker Robin van Persie after being drawn in a tough Europa League group yesterday alongside Fenerbahce, Feyenoord and Zorya Luhansk.
Three-times European champions United must negotiate a competitive group if they are to win one of the few titles that has eluded them.
The Premier League side will face 19-times Turkish champions Fenerbahce, who missed out on the Champions League group stage after a 4-3 aggregate defeat by Monaco in the third qualifying round.
They are managed by former Netherlands coach Dick Advocaat and include ex-United forward Van Persie who began his career with Feyenoord.
The Dutch Cup holders finished third in the Eredivisie last season. Zorya qualified as Ukraine’s fourth-placed team.
Southampton have been drawn alongside Inter, Sparta Prague and Hapoel Be’er Sheva.
Villarreal, beaten semi-finalists last season, meet former European champions Steaua Bucharest, FC Zurich and Osmanlispor.
Group-stage first-timers Dundalk of Ireland meet AZ Alkmaar, Maccabi Tel Aviv and Zenit St. Petersburg, who reached the Champions League round of 16 last season.
The top two teams from each of the 12 groups advance to the round of 32 where they will be joined by the eight third-placed teams from the Champions League group stage.
The final will be played in Stockholm on May 24.
Group A – Manchester United; Fenerbahce; Feyenoord; Zorya Luhansk.
Group B – Olympiakos; Apoel Nicosia; Young Boys; Astana.
Group C – Anderlecht St Etienne Mainz Qabala.
Group D – Zenit SP; AZ Alkmaar; Maccabi Tel Aviv; Dundalk.
Group E – V. Plzen; Roma; Austria Vienna; Astra Giurgiu.
Group F – Athletic Bilbao; Genk; Rapid Vienna; Sassulo.
Group G – Ajax; Standard Liege; Celta Vigo; Panathinaikos.
Group H – Shakhtar Donetsk; Braga; Gent; Konyaspo.r
Group I – Schalke 04; Salzburg; Krasnodar; Nice.
Group J – Fiorentina; PAOK; Slovan Liberec; Qarabag.
Group K – Inter; Sparta Prague; Southampton; Hapoel Be’er Sheva.
Group L – Villarreal; Steaua Bucharest; Zurich; Osmanlispor.