Paul Manafort has resigned from the campaign of US Republican presidential candidate Donald Trump, days after he was effectively demoted in a shake-up of the campaign leadership.

"This morning Paul Manafort offered, and I accepted, his resignation from the campaign," Trump said in a statement. "I am very appreciative for his great work in helping to get us where we are today, and in particular his work guiding us through the delegate and convention process. Paul is a true professional and I wish him the greatest success."

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