Manchester City reached the semi-finals of the Champions League for the first time in their history but they went down to Real Madrid who went on to win the trophy in Milan.
Rivals Manchester United missed out on qualification to the Champions League and will figure in the less glamorous Europa League after finishing fifth in the English Premier League last season.
Both City and United have appointed new managers with Pep Guardiola now in charge at the Etihad Stadium while Jose Mourinho has taken over from Louis van Gaal at Old Trafford.
The Manchester City owners committed a huge mistake when announcing that Guardiola will replace Manuel Pellegrini midway through the season as the Citizens lost their plot, finishing fourth and gathering 66 points, their lowest total since 2009-10.
United, like their neighbours City, lost a total of 10 league games.
Dutchman Van Gaal wanted his team to dominate possession but his biggest concern was how easily the team fell apart when pressed, and their vulnerability when defending set-pieces.
On a positive note, the FA Cup triumph at Wembley was a nice way to end a disappointing campaign.
In the Europa League, United were knocked out by Liverpool
KO competitions
The two Manchester clubs claimed the domestic cups, City lifting the League Cup after winning a penalty shoot-out against Liverpool in the final while United beat Crystal Palace 2-1 after extra-time in the FA Cup final.
In the League Cup, United lost to Middlesbrough 1-3 on penalties in round four at Old Trafford while City were knocked out by Chelsea in the FA Cup fifth round.
English Premier League results – 2015/16
Manchester City
August
Away vs West Brom 3-0 (Toure 2, Kompany).
Home vs Chelsea 3-0 (Aguero, Kompany, Fernandinho).
Away vs Everton 2-0 (Kolarov, Nasri).
Home vs Watford 2-0 (Sterling, Fernandinho).
September
Away vs Crystal Palace 1-0 (Iheanacho).
Home vs West Ham 1-2 (De Bruyne).
Away vs Tottenham 1-4 (De Bruyne).
October
Home vs Newcastle 6-1 (Aguero 5, De Bruyne).
Home vs Bournemouth 5-1 (Sterling 3, Bony 2).
Away vs Manchester United 0-0.
Home vs Norwich 2-1 (Otamendi, Toure pen).
November
Away vs Aston Villa 0-0.
Home vs Liverpool 1-4 (Aguero).
Home vs Southampton 3-1 (De Bruyne, Delph, Kolarov).
December
Away vs Stoke 0-2.
Home vs Swansea 2-1 (Bony, Iheanacho).
Away vs Arsenal 1-2 (Toure).
Home vs Sunderland 4-1 (Sterling, Toure, Bony, De Bruyne).
Away vs Leicester 0-0.
January
Away vs Watford 2-1 (Toure, Aguero).
Home vs Everton 0-0.
Home vs Crystal Palace 4-0 (Delph, Aguero 2, Silva).
Away vs West Ham 2-2 (Aguero 2, 1 pen).
February
Away vs Sunderland 1-0 (Aguero).
Home vs Leicester 1-3 (Aguero).
Home vs Tottenham 1-2 (Iheanacho).
March
Away vs Liverpool 0-2.
Home vs Aston Villa 4-0 (Toure, Aguero 2, Sterling).
Away vs Norwich 0-0.
Home vs Manchester United 0-1.
April
Away vs Bournemouth 4-0 (Fernando, De Bruyne, Aguero, Kolarov).
Home vs West Brom 2-1 (Aguero pen, Nasri).
Away vs Chelsea 3-0 (Aguero 3, 1 pen).
Away vs Newcastle 1-1 (Aguero).
Home vs Stoke 4-0 (Fernando, Aguero pen, Iheanacho 2).
Away vs Southampton 2-4 (Iheanacho 2).
May
Home vs Arsenal 2-2 (Aguero, De Bruyne).
Away vs Swansea 1-1 (Iheanacho).
Manchester United
August
Home vs Tottenham 1-0 (Walker og).
Away vs Aston Villa 1-0 (Januzaj).
Home vs Newcastle 0-0.
Away vs Swansea 1-2 (Mata).
September
Home vs Liverpool 3-1 (Blind, Herrera pen, Martial).
Away vs Southampton 3-2 (Martial 2, Mata).
Home vs Sunderland 3-2 (Depay, Rooney, Mata).
October
Away vs Arsenal 0-3.
Away vs Everton 3-0 (Schneiderlin, Herrera, Rooney).
Home vs Manchester City 0-0.
Away vs Crystal Palace 0-0.
November
Away vs Watford 2-1 (Deeney og, Depay).
Home vs West Brom 2-0 (Lingard, Mata pen).
Away vs Leicester 1-1 (Schweinsteiger).
December
Home vs West Ham 0-0.
Away vs Bournemouth 1-2 (Fellaini).
Home vs Norwich 1-2 (Martial).
Away vs Stoke 0-0.
Home vs Chelsea 0-0.
January
Home vs Swansea 2-1 (Martial, Rooney).
Away vs Newcastle 3-3 (Rooney 2, 1 pen, Lingard).
Away vs Liverpool 1-0 (Rooney).
Home vs Southampton 0-1.
February
Home vs Stoke 3-0 (Lingard, Martial, Rooney).
Away vs Arsenal 1-1 (Lingard).
Away vs Sunderland 1-2 (Martial).
Home vs Arsenal 3-2 (Rashford 2, Herrera).
March
Home vs Watford 1-0 (Mata).
Away vs West Brom 0-1.
Away vs Manchester City 1-0 (Rashford).
April
Home vs Everton 1-0 (Martial).
Away vs Tottenham 0-3.
Home vs Aston Villa 1-0 (Rashford).
Home vs Crystal Palace 2-0 (Delaney og, Darmian).
May
Home vs Leicester 1-1 (Martial).
Away vs Norwich 1-0 (Mata).
Away vs West Ham 2-3 (Martial 2).
Home vs Bournemouth 3-1 (Rooney, Rashford, Young).