Napoli continued to cut a swathe through the Europa League, blowing away FC Midtjylland 5-0 to qualify from Group D with two games to spare.
The Serie A side made it four wins in a row, and took their goals scored to 16 with goals from Omar El Kaddouri, Manolo Gabbiadini (two), Christian Maggio and Jose Maria Callejon.
Rapid Vienna progressed to the knock-out stage from Group E after continuing their 100 per cent record with a 2-1 win at Viktoria Plzen.
Philipp Schobesberger scored both goals for the Austrians, with Jan Polenda having briefly equalised.
Roberto Soldado scored twice as Villarreal came from behind to take all three points with a 2-1 success at Dinamo Minsk, who have now lost all four.
Borussia Dortmund extended their club scoring record, netting for the 31st competitive game in a row.
They were 4-0 winners over Qabala, with Marco Reus, Pierre-Emerick Aubameyang, Sergei Zenjov (own goal) and Henrik Mkhitaryan completing the walkover.
Krasnodar defeated PAOK Salonika 2-1 to stay second behind Dortmund.
History was made at Celtic Park too, where 40-year-old Daniel Hestad became the oldest scorer in the competition's history as Molde progressed.
He grabbed the winner in a 2-1 success over 10-man Celtic, Mohamed Elyounoussi and Kris Commons having cancelled each other's goals out.
Ajax and Fiorentina drew 0-0 in Group A's other game.
Liverpool continued their upturn in form under Jurgen Klopp, winning for the first time in Group B, Jordan Ibe securing a 1-0 victory at Rubin Kazan.
That put Liverpool second, behind FC Sion who drew 1-1 with Bordeaux.
Thomas Meunier scored the only goal of the game as Club Brugge recorded their first win, at home to Legia Warsaw in Group D.
In Group F, Marseille denied Braga the chance to guarantee a place in the next round, Georges N'Koudou on target in a 1-0 triumph.
Sergio Padt's own goal gave Liberec the win over Groningen by the same scoreline.
Group H rivals Besiktas and Lokomotiv Moscow drew 1-1, as did Qarabag and Monaco in Group J.
Tottenham leapfrogged Monaco atop Group J thanks to a wonderful finish from Mousa Dembele three minutes from time.
Harry Kane had put Spurs ahead in the first half before Imoh Ezekiel levelled in the 72nd minute.
Schalke missed the chance to seal a spot in the next round, drawing 1-1 against Sparta Prague.
Asteras Tripolis got their first win in Group K, 2-0 at home over Apoel Nicosia.
Two Group L games shared 11 goals, Athletic Bilbao and Augsburg firmly on the goal trail.
Inaki Williams scored the first two in Athletic's 5-1 win over Partizan Belgrade, while Aritz Aduriz added his 100th career goal for the club.
Augsburg thrashed AZ Alkmaar 4-1, with Raul Bobadilla netting a hat-trick.
Marc Janko and Breel Embolo hit the target as Group I pace-setters Basle made it nine points from 12 with a 2-0 victory over Belenenses.
Fiorentina jumped from fourth to second as Josip Ilicic scored both in a 2-0 away win at Lech Poznan.
Group H leaders Lokomotiv Moscow were held 1-1 at Besiktas and Sporting Lisbon went down 3-0 at Skenderbeu after a first-half red card for Rui Patricio.
Lazio and St Etienne strengthened their hold on the top two spots in Group G, Filip Djordjevic with both in the Italians' 2-0 win over visiting Dnipro and the Ligue 1 outfit with a 3-0 defeat of Rosenborg.