The Williams Family show took centre stage at the US Open with Serena and Venus both cruising to straight set wins to set up a monster quarter-final between the tennis siblings.

Whenever the Williams sisters clash on court it is a major tennis event but with older sister Venus, a twice US Open winner, standing in the way of defending champion Serena’s quest for a rare calendar-year grand slam their meeting tonight has been elevated to a must-see sporting viewing.

While the National Tennis Center was abuzz over another Williams grand slam showdown, world no.1 Novak Djokovic was hard at work taming Roberto Bautista Agut 6-3 4-6 6-4 6-3 to reach his 26th consecutive grand slam quarter-final.

Only Roger Federer (36) and Jimmy Connors (27) have registered more consecutive grand slam quarter-final appearances than Djokovic since the slams began including professionals in 1968.

With Serena bidding to become just the fourth woman to win all four grand slams in the same year, the US Open hype machine that already had been in top gear is now set to crank into overdrive.

The Williams sisters have met 26 times over their careers with Serena coming out on top 15-11 but meeting no.27 will have more than the usual family bragging rights riding on the outcome.

“Obviously getting to a Grand Slam semi-final is the next step toward the final. Pretty clear what’s up for grabs here,” said Venus.

“I think people love to see history being made. No one is out to be a spoiler, but at the same time, you’re focused on winning your match even though the circumstances are really much different than you.”

The 35-year-old Venus, seeded 23rd, overpowered 19-year-old qualifier Estonian Anett Kontaveit 6-2 6-1 in a ruthless fourth-round display that took just 50 minutes.

Serena followed her sister onto Arthur Ashe Stadium court and was no less efficient, routing fellow American Madison Keys 6-3 6-3 in 68 minutes.

“She’s playing great,” Serena said about seven-times grand slam winner Venus, who is two years her elder.

“I have to really be ready for that. At least one of us, a Williams, will be in the semis.”

Defending champion Marin Cilic kicked off centre court action on another sunny day at Flushing Meadows and was the first man through to the last eight, taking down determined Frenchman Jeremy Chardy 6-3 2-6 7-6 6-1 to extend his US Open win streak to 11 matches.

Coming off a punishing five-setter with Mikhail Kukushkin in a third-round match that lasted four hours, Cilic took a while to find his power game but was unstoppable once he did, the ninth seeded Croat blasting 23 aces past 27th seed Chardy, who had no answer.

Cilic said: “I played really great tennis, so I’m happy about it.”

After splitting the opening two sets, Cilic’s power began to show through, particularly in the third set tiebreak when he used his big serve to full advantage firing four aces before closing out 7-2.

Four Frenchmen made the round of 16, a US Open record, and at least one advanced to the quarter-finals, with Jo-Wilfried Tsonga beating Benoit Paire 6-4 6-3 6-4.

Italian Fabio Fognini, who toppled Rafa Nadal in an epic five-setter that ended early Saturday morning, had nothing left in his tank for his fourth-round clash with Spaniard Feliciano Lopez, the 18th seeded easing to a 6-3 7-6 6-1 win.

Fourth round results: (Women) Azarenka bt Lepchenko 6-3 6-4; (Men) Wawrinka bt Young 6-4 1-6 6-3 6-4.

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