Brothers Adrian and Robert Farrugia are among 50 people being investigated by Italian police over alleged match fixing in Lega Pro and Serie D matches.
Adrian Farrugia, a former player, was team manager of Mosta FC, a position he resigned from just a few days ago.
Robert Farrugia is council member of Msida St Joseph and a former president of the club.
A number of arrests were made but the Italian police said they have not found the Maltese brothers. It is now up to the Italian magistrate to seek an extradition order for the brothers.
An Italian closely involved with a Malta club is also listed among the people under investigation.
Italian media said 70 other people are being questioned.
Those arrested included players and directors from around 30 clubs who were under suspicion of "conspiracy to commit sporting fraud".
The operation, which according to Gazzetta dello Sport is code-named "Dirty Soccer", is being coordinated by prosecutors in the southern town of Catanzaro.
A spokesman for the Malta Football Association said the MFA was aware of the allegations but for the time being this was a police matter.
"The probe demonstrates there was a heinous pact of corruption in the world of soccer," Andrea Grassi, investigator for Italy's elite SCO, an Italian anti-mafia police unit, told Reuters.
"It shows the interest of criminal networks in the business generated by soccer and the legal betting industry."
The investigation began when police tapped the telephone of a member of the Iannazzo mob family in Calabria, discovering that he was arranging matches in order to make money by betting on them, a police official told Reuters.
The charges included conspiracy to commit sporting fraud, which in some cases favoured organised crime groups. The continuing investigation also includes second division, or Serie B, games, police said.
Investigators suspect 28 Lega Pro and Serie D matches from the 2014-15 season were rigged. Among those sought by police for bribing players and coaches were Serbs, Albanians and Maltese nationals.
Police across Italy rounded up suspects in the early hours -- including 27 team presidents and managers, 17 players, five coaches, and one police officer -- and raided club offices.
Italy has been rocked by other match-fixing scandals in recent years. Mafia groups have increasingly tapped into the country's legal gambling industry, Europe's largest, as a way to earn and launder money.
The previous scandal followed the 2010-11 season, when the results of Serie B and third division -- Lega Pro -- matches were discovered to have been set up.
In the latest scandal, investigators said there were two different criminal gangs, one to set up the games in Lega Pro and the other those in Serie D.
"In some cases they fixed the matches in a hotel room," a police official said, saying that there was video surveillance of at least one meeting.
Some of the clubs targeted by the investigation are Pro Patria, Barletta, Brindisi, L'Aquila, Neapolis, Mugnano, Torres, Vigor-Lametia, Santarcangelo, Sorrento, Montalto, Puteolana, Akragas and San Severo, police said.