Napoli won 2-1 at Genoa thanks to a stoppage-time goal by Jonathan de Guzman and Inter defender Nemanja Vidic began his Serie A career by giving away a penalty and getting sent off in a 0-0 draw at Torino.

Thirty-six-year-old Antonio Di Natale, who back-tracked on last season's decision to retire, was as sharp as ever, scoring both goals in Udinese's 2-0 win over promoted Empoli to follow his four-goal haul in the Coppa Italia last week.

Milan gave Filippo Inzaghi a winning start as coach by beating Lazio 3-1, helped by an inspired debut from goalkeeper Diego Lopez who capped his performance by saving a penalty in stoppage time.

Sampdoria trailed for 83 minutes at promoted Palermo and played the entire second half with 10 men after Vasco Regini was sent off, but still managed to draw 1-1 thanks to a goal by Daniele Gastaldello in the last minute.

Napoli took an early lead at Genoa through Jose Callejon but the hosts levelled just before halftime with a superb header by Chile forward Mauricio Pinilla on his debut following his move from Cagliari.

Napoli, who failed to qualify for the Champions League after losing 3-1 to Athletic Bilbao due to a shambolic defensive display, grabbed the three points when Dutchman De Guzman sneaked in behind the Genoa defence at a free kick to score from close range.

Vidic conceded a first-half penalty with a foul on Fabio Quagliarella against Torino but his blushes were spared when Samir Handanovic saved Marcelo Larrondo's spot-kick.

The former Manchester United defender was sent off near the end of the match, however, for sarcastically applauding the referee.