Play-off round, first legs
| 1st leg | 2nd leg | Agg. | |
| Aktobe (Kazakhstan) vs L. Warsaw (Poland) | 0-1 | ||
| Apollon (Cyprus) vs Lok. Moscow (Russia) | 1-1 | ||
| Astana (Kazakhstan) vs Villarreal (Spain) | 0-3 | ||
| Asteras Tripolis (Greece) vs M. Tel-Aviv (Israel) | 2-0 | ||
| Dinamo Minsk (Belarus) vs Nacional (Portugal) | 2-0 | ||
| Dnipro (Ukraine) vs Hajduk Split (Croatia) | 2-1 | ||
| Elfsborg (Sweden) vs Rio Ave (Portugal) | 2-1 | ||
| Zorya Luhansk (Ukraine) vs Feyenoord (Holland) | 1-1 | ||
| Grasshopper (Switzerland) vs Bruges (Belgium) | 1-2 | ||
| HJK Helsinki (Finland) vs Rapid Wien (Austria) | 2-1 | ||
| HNK Rijeka (Croatia) vs FC Sheriff (Moldova) | 1-0 | ||
| Limassol (Cyprus) vs Tottenham (England) | 1-2 | ||
| Lokeren (Belgium) vs Hull City (England) | 1-0 | ||
| Lyon (France) vs Astra (Romania) | 1-2 | ||
| Karabukspor (Turkey) vs St Etienne (France) | 1-0 | ||
| Partizan Belgrade (Serbia)vs Neftci (Azerbaijan) | 3-2 | ||
| Dinamo Moscow (Russia) vs Omonia (Cyprus) | 2-2 | ||
| Panathinaikos (Greece) vs Midtjylland (Denmark) | 4-1 | ||
| Petrolul (Romania) vs Dinamo Zagreb (Croatia) | 1-3 | ||
| PSV (Holland) vs Shaktyor Soligorsk (Belarus) | 1-0 | ||
| Qarabag (Azerbaijan) vs Twente (Holland) | 0-0 | ||
| Real Sociedad (Spain) vs Krasnodar (Russia) | 1-0 | ||
| RNK Split (Croatia) vs Torino (Italy) | 0-0 | ||
| Ruch Chorzow (Poland) vs M. Kharkiv (Ukraine) | 0-0 | ||
| Sarajevo (Bosnia) vs B. M’gladbach (Germany) | 2-3 | ||
| Spartak Trnava (Slovakia) vs Zurich (Switzerland) | 1-3 | ||
| Stjarnan (Iceland) vs Inter (Italy) | 0-3 | ||
| Trabzonspor (Turkey) vs Rostov (Russia) | 2-0 | ||
| Young Boys (Switzerland) vs Debrecen (Hungary) | 3-1 | ||
| Zimbru (Moldova) vs PAOK (Greece) | 1-0 | ||
| Zwolle (Holland) vs Sparta Prague (Czech Rep.) | 1-1 |
Second legs: August 28.