Man. United’s Ashley Young (left) in a duel with George McCartney.

Tonight’s Manchester derby is the highlight of five midweek matches as the Premier League continues almost without pausing for breath following another eventful weekend’s football in England.

Manchester United, 18 points behind leaders Chelsea, have no chance of retaining their title but are keen to stop third-placed Manchester City succeeding them as champions.

Badly beaten 4-1 by their local rivals in September, United have home advantage this time and go into the game buoyed by successive victories over Olympiakos, to reach the Champions League quarter-final, and West Ham.

Saturday’s 2-0 win at Upton Park, where acting captain Wayne Rooney scored one of the goals of the season from more than 50 metres, helped ease the pressure from manager David Moyes, who has struggled in his first season after taking over from Alex Ferguson.

“You get three points for winning any game but there is an added importance of winning the big games,” Moyes told reporters.

“It’s not been something we have done well enough this season, so it would be nice if we could get it in this game.

“Their ability to score goals would be in anybody’s mind because if you look at the record this year they have been terrific.”

City trail Chelsea by six points but have three games in hand and with a superior goal difference would go top by winning two of them.

They will again be without their leading scorer, Argentinian striker Sergio Aguero, who has a hamstring injury but captain Vincent Kompany is available after suspension.

City have been solid in defence, not conceding in the last three league games, but despite scoring five times without reply against bottom-of-the-table Fulham on Saturday, their total of 76 goals is now six fewer than rampant Liverpool.

Brendan Rodgers’s side have joined the title chase with six successive victories, scoring 24 goals in the process. Having won 6-3 at Cardiff at the weekend, they will be expected to defeat another of the relegation-threatened sides, Sunderland, at Anfield tomorrow.

For Sunderland, it is one of two games in hand on the teams immediately above them. Swansea City, four points in front of Gus Poyet’s side, have dropped into the bottom six and will fear a backlash today in their game at Arsenal.

The London side suffered a humiliating 6-0 defeat by Chelsea on Saturday.

Arsenal will have both defender Kieran Gibbs and midfielder Alex Oxlade-Chamberlain available after appeals to the Football Association.

Gibbs was shown a red card in a case of mistaken identity during the first half against Chelsea by referee Andre Marriner, instead of Oxlade-Chamberlain ­­− who had committed the handball in the six-yard box.

The FA confirmed the sanction against Gibbs had been removed, and instead transferred onto Oxlade-Chamberlain. However, Arsenal then moved to have that offence downgraded on appeal, claiming the midfielder had not in fact prevented a goalscoring opportunity as the shot from Eden Hazard looked to be going just wide.

That claim was also upheld, meaning both Gibbs and Oxlade-Chamberlain can face Swansea.

Playing today
Arsenal vs Swansea City - 20.45
Man. United vs Man. City - 20.45
Newcastle vs Everton - 20.45

Tomorrow
West Ham vs Hull - 20.45
Liverpool vs Sunderland - 21.00