Stanislas Wawrinka... ended Novak Djokovic’s reign in Melbourne.

Stanislas Wawrinka brought a dramatic end to Novak Djokovic’s quest for a fourth successive Australian Open title in the quarter-finals yesterday when he finally found a way to beat the Serbian in a grand slam five-setter.

The pair held a packed Rod Laver Arena spellbound with four hours of top quality tennis studded with breathtaking rallies before the Swiss emerged a 2-6 6-4 6-2 3-6 9-7 winner to snap a 14-match losing streak against the second seed.

Wawrinka had come close to beating Djokovic in a five-hour epic in the fourth round in Melbourne last year and another five-set thriller in the semi-finals of the US Open last September – only to fall agonisingly short.

The 28-year-old finished the job yesterday, though, riding his thunderous serve and summoning up some brilliant shot-making, particularly off his backhand, to claim what could be a career-defining win when Djokovic fluffed a volley.

“He’s an amazing champion, he never gives up. I’m really happy,” said Wawrinka, whose path to a first grand slam final is blocked by Czech Tomas Berdych.

“After losing two times against him in grand slam in five sets, I’m really happy to take that one. It’s great for me.”

Defeat for Djokovic in his first major tournament under new co-coach Boris Becker ended his run of consecutive grand slam semi-finals at 14, his winning streak in tour events at 28 matches and his unbeaten run at Melbourne Park at 25.

“This is probably the court where I had most excitement in my tennis career,” said the four-times champion.

“These are kind of matches that you work for, you live for, you practise for. Unfortunately somebody has to lose in the end. This year it was me. I lost to a better player.”

Czech Berdych came out on top 6-1 6-4 2-6 6-4 in a three-hour arm-wrestle against David Ferrer to reach the last four at the year’s first grand slam for the first time.

Canadian teenager Eugenie Bouchard had earlier kept her poise in the biggest match of her life to oust Ana Ivanovic 5-7 7-5 6-2 and set up a semi-final against China’s Li Na, who dispatched Flavia Pennetta 6-2 6-2.

Ivanovic had cleared her own path to the final by upsetting world number one Serena Williams in the fourth round but was unable to take advantage against Bouchard.

The Serbian looked on course for a first grand slam semi-final since her 2008 French Open triumph after clinching the first set but Bouchard charged straight back into the contest to tie it up at 1-1 on an Ivanovic double fault.

Ivanovic tried to wrest back the momentum but as much as she ramped up her formidable forehand, there was no putting this particular Genie back in the bottle.

Bouchard lost her composure only once, when she was asked in her on-court interview who she would most like to date and declared a liking for pop star Justin Bieber.

Li’s victory was, by contrast, a stroll by the banks of the Yarra River as she blasted her 28th-seeded opponent off the court to reach the semi-finals for the fourth time in five years.

After her victory, Li entertained the crowd on Rod Laver Arena with another of the interviews that have made her a firm favourite at Melbourne Park – this time about how she would never smash a racket as she considers them friends.