Defending champion Andy Murray was the latest grand slam winner to be bundled out of the US Open and deny fans a dream match-up, while Novak Djokovic stayed the course on Thursday to complete the last four line-up.

Winds blew across Arthur Ashe Stadium but that did not bother top seed Djokovic, who defeated Mikhail Youzhny 6-3 6-2 3-6 6-0 to claim a berth in today’s semi-finals.

An eagerly-anticipated renewal of his grand slam rivalry with Wimbledon winner Murray had already been spoiled after ninth seed Stanislas Wawrinka, of Switzerland, spanked the out-of-sorts Scot 6-4 6-3 6-2 in their quarter-final.

The other semi-final will have French Open champion Rafa Nadal against eighth-seeded Frenchman Richard Gasquet.

“I’m always trying to play my best tennis in the grand slams,” said world number one Djokovic, who reached his 14th consecutive grand slam semi-final.

“I’m really working on my game.”

Wawrinka stepped out from the shadow cast by compatriot Roger Federer and into his first grand slam semi-final with a decisive victory over the Wimbledon champion, winning the battle from the baseline and the net.

The surging Wawrinka, who raised his 2013 record to 41-15 with the upset win, raised both arms in triumph after third seed Murray dumped a second-serve return into the net on match point.

“It feels amazing for sure, especially here,” the excited Swiss said.

“He’s defending champion, he’s a tough opponent. It was a crazy match for me. To beat him in three sets is just amazing.”

Wawrinka broke Murray four times and never faced a break point against a player noted for his ability to return. He cracked 45 winners past the listless Murray and won 31 of 42 forays to the net in the one-sided match.

Murray admitted to a Wimbledon hangover after ending a drought of 77 years without a British winner since Fred Perry’s 1936 triumph at the All England Club.

“When you work hard for something for a lot of years, it’s going to take a bit of time to really fire yourself up and get yourself training 110 per cent,” he said.

“That’s something that I think is kind of natural after what happened at Wimbledon,” added Murray, who beat Djokovic in the Wimbledon final and to win the 2012 US Open title while losing the Australia Open final to the Serb in between.

“But I got here. I got to the quarter-finals, which isn’t easy.”

Murray’s loss was the second seismic shocker to strike the men’s draw in the last two rounds of the US Open following the straight sets dismissal of Federer in the fourth round by Tommy Robredo.

Robredo’s victory robbed fans of a quarter-finals match between Federer and Nadal that would have marked the first US Open meeting between the two, who have met 31 times elsewhere around the world.

Djokovic, one week younger than his friend and fellow 26-year-old Murray, would seem to benefit from the shuffle.

The Serb has a narrow 11-8 career mark against Murray, having won their first four meetings at the start of their careers, but is 12-2 including the last 11 against Wawrinka.

Women’s SF: Azarenka bt Pennetta 6-4 6-2.

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