Barcelona versus Milan and Manchester United against Real Madrid were the pick of the ties in the Champions League last 16 draw yesterday, as the knock-out phase of this year’s competition took shape.

Perennial favourites Barce-lona, champions in 2009 and 2011, are currently nine points clear in La Liga but received a hammer blow on Wednesday when it was revealed coach Tito Vilanova must undergo surgery after cancer returned to his salivary gland.

His assistant, Jordi Roura, has been placed in temporary charge.

Barcelona and Milan locked horns four times in last season’s competition, with Barca finishing above Massimiliano Allegri’s side in the group phase and then prevailing 3-1 on aggregate when they met again in the last eight.

United’s tie with Real Madrid will see Portugal skipper Cristiano Ronaldo face his former club for the first time since leaving Old Trafford for the Spanish capital in 2009.

The sides last met in 2003, when a famous hat-trick in Manchester by Ronaldo – Cristiano Ronaldo’s Brazilian predecessor and namesake – gave Madrid a 6-5 aggregate quarter-final win.

Real Madrid coach Jose Mourinho has only lost two of his 14 previous encounters with Alex Ferguson’s side, and United club secretary John Alexander admitted the club would have preferred a more gentle draw.

“Everyone wanted to keep this for later in the competition but, out of several stand-out ties, I think this is the one,” he told British television channel Sky Sports News.

“If history has anything in our favour, our one victory against Real Madrid in this competition was in the season when we won the final at Wembley (in 1968).”

Former Madrid player and club director Emilio Butragueno said: “I’m sure it’s going to be a special game for Ronaldo.

“He’s a great professional so I’m sure he’s going to do his best to help Real Madrid qualify for the next round, but going back there will be special for him.”

Arsenal-Bayern

Arsenal were drawn against last season’s beaten finalists, Bayern Munich, who have constructed a nine-point lead in the Bundesliga after a storming start to the season.

“We know Arsenal well,” said Bayern chairman Karl-Heinz Rummenigge.

“That’s fortunate and we can be happy about the draw. The game won’t be a foregone conclusion and we should not underestimate Arsenal.”

Meanwhile, Celtic’s reward for reaching the knock-out phase for the first time since 2007-08 is a rendezvous with Italian champions Juventus.

Big-spending French club Paris Saint-Germain will take on Valencia, with German champions Borussia Dortmund slated to face their Ukrainian counterparts Shakhtar Donetsk.

In the remaining ties, competition debutants Malaga tackle Porto and Turkish outfit Galatasaray meet German side Schalke.

In a remarkable quirk, the draw for the matches in February and March produced exactly the same ties as had been drawn in Wednesday’s rehearsal.

Last 16 draw

February 12

Celtic vs Juventus
Valencia vs Paris SG
Second leg: March 6

February 13

S. Donetsk vs Bor. Dortmund
Real Madrid vs Man. United
Second leg: March 5

February 19

Porto vs Malaga
Arsenal vs Bayern Munich
Second leg: March 13

February 20

Galatasaray vs Schalke 04
Milan vs Barcelona
Second leg: March 12

Final
May 25 – Wembley Stadium, London

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