Lionel Messi became the first player to score five goals in a Champions League tie as Barcelona routed Bayer Leverkusen 7-1 to reach the quarter-finals with a crushing 10-2 aggregate win last night.

Messi bettered his previous record of four against Arsenal two seasons ago and now has 12 goals from seven Champions League matches after a majestic attacking performance from the World Player of the Year.

In Cyprus, Dionissis Chiotis was the hero as he saved twice in a penalty shootout to send Apoel Nicosia into the quarter-finals at the expense of Lyon.

With the score level at 3-3 in the shootout, Chiotis saved successive penalties from Alexandre Lacazette and Michel Bastos to secure his side a place in the last eight on their first appearance in the knockout stages.

Trailing 3-1 from the first leg it was always going to be a tough task for Bayer with Barca unbeaten in 13 European home games and they never appeared likely to end that run.

Messi struck twice before the break and then hit a further three after the restart while youngster Christian Tello also grabbed a brace.

In the final minute, Karim Bellarabi scored for a shell-shocked German side.

“You can expect anything from Leo,” said team-mate Cesc Fabregas.

“He is the best player in history, we have never seen anyone like him. He didn’t play at the weekend (Messi was suspended) and he wanted to do well.

“He enjoys being on the pitch and we are happy to have him.”

Barcelona were without Carles Puyol and Eric Abidal in defence and Alexis Sanchez was also in the treatment room after pulling up with a strain in the weekend 3-1 victory over Sporting Gijon.

Bayer coach Robin Dutt said beforehand that his team would go out to enjoy themselves without any pressure on their shoulders.

But once the game was underway there was little chance for the Germans to savour the moment of playing at the Camp Nou as they were immediately pegged back.

With important games ahead and Barca leading 3-0, coach Pep Guardiola chose to take off Iniesta and Xavi after 52 minutes with Tello and Seydou Keita coming on.

But there was no let up in Barca’s thrust even though in the 90th minute Bellarabi did manage to register a goal for Bayer, curling the ball into the corner.

Gustavo Manduca scored the only goal of the night in Nicosia to cancel out Lacazette’s winner for Lyon in the first leg.

Manduca’s night ended on a sour note when he picked up a second booking in the 115th minute but his team-mates – and Chiotis in particular – ensured his dismissal was not a precursor to their elimination.

Apoel had every reason to be confident coming into the match thanks to their record of just one defeat in their last 10 home European games.

Leading scorers
12: Messi (Barcelona).
6: Gomez (Bayern Munich).
5: Soldado (Valencia), Gomis (Lyon), Doumbia (CSKA Moscow), Alexander Frei (Basel), Ibrahimovic (Milan), Shirokov (Zenit), Cavani (Napoli).

Last 16, 2nd legs

Played yesterday

Barcelona 7
Messi 25, 42, 49; Messi 58, 84; Tello 55, 62;
B. L’erkusen 1
Bellarabi 90;

(Barcelona win 10-2 on aggregate)

Apoel FC 1
Manduca 9;
Lyon 0

(agg: 1-1; Apoel win 4-3 on penalties)

Played Tuesday

Arsenal 3
Milan 0

(Milan win 4-3 on aggregate)

Benfica 2
Zenit SP 0

(Benfica win 4-3 on aggregate)

March 13
Inter vs Marseille (0-1)
Bayern Munich vs Basel (0-1)

March 14
Chelsea vs Napoli (1-3)
Real Madrid vs CSKA (1-1)

Note: First leg results in brackets.