Wrong strategy could worsen dengue epidemics – study

The wrong approach to wiping out the mosquitoes that cause dengue infections could lead to worse epidemics in the future, according to a study.

Targeting only mosquito larvae, and not adults, insecticides may work in the short run, but could result in higher resistance in the insects and less disease immunity among humans, especially in urban settings, the study found.

Dengue is a mosquito-borne infection that causes severe, flu-like symptoms in some 50 million people every year, mainly in developing countries.

Global incidence of the disease, which is rarely fatal but often debilitating, has risen dramatically in recent decades, linked to both rapid urbanisation and the impact of global warming. Some 2.5 billion people are at risk.

There is no treatment, cure or vaccine – the only way to control the disease is to kill the mosquitoes that carry it, especially one species: Aedes aegypti.

But which insecticides work best, how frequently they should be applied and whether it is more effective to target mosquitoes in their larval or adult stage are still debated among experts. Re-searchers led by Paula Luz of the Oswaldo Cruz Foundation in Rio de Janeiro used mathematics and computer models to simulate the impact over five years of dozens of different strategies for reducing the vectors in which the blood-seeking insects breed and live. The cost of different approaches was also taken into account, using World Health Organisation (WHO) guidelines as to “cost-effectiveness”, that is, the trade-off between results and the price tag.

The method prevailing in most countries – attempting to destroy breeding areas – is misguided, according to the study, published in The Lancet. “Year-round larval control can be counterproductive, exacerbating epidemics in later years because of evolution of insecticide resistance and loss of herd immunity,” the researchers said.

“Herd immunity” is the term scientists use to describe immunity that occurs when enough of the population is inoculated from having had the disease to prevent it from spreading easily.