For three-quarters of a century, the cane toad has rampaged around northeastern Australia, but scientists hope the toxic terror may at last be stopped in its tracks.

A native of central America, the cane toad (Bufo marinus) was introduced to Australia in 1935 to kill beetles devastating sugar-cane crops, only to become a pest in its own right.

But a new investigation says that the toad – up to 25 centimetres long and two kilos in weight – has an Achilles’ heel.

Unlike indigenous amphibians that have adapted to arid conditions, the imported anuran desperately needs access to nearby standing water in order to survive.

Placing small fencing around man-made sources such as irrigation ditches and troughs is enough to cause the toad to die of dehydration and stop its advance, says the study.

“Basically, step by step, toads use these water points to invade the drier regions of Australia,” said University of Melbourne researcher Tim Dempster.

“By stopping toads from using these water points, we are removing their ‘stepping stones’ in the landscape.”

Mr Dempster’s team experimented with cane toads which were placed near nine artificial water points during the dry season in the Victoria River District of the Northern Territory.

Some of the water points were unfenced but others were surrounded by cloth netting 60 centimetres high that also extended along the ground to stop the large toads from burrowing underneath. The netting was secured by wire and metal posts at least two metres from the water’s edge.

All 21 toads placed near fenced-off water points died, and most of them expired within 12 hours.

Of the 20 toads with unfettered access to water, all survived except for one, which was killed by a predatory bird.

Mr Dempster said that fencing off even a small number of key water points can halt further invasion and save a million square kilometres – an area roughly twice the size of France – out of the 2.24 million square kilometres of arid land threatened by the beasts.

“The greatest benefit from the technique will be to stop further invasion into several of Australia’s drier inland areas which are hotspots of unique native animal biodiversity,” Mr Dempster said.

The method is feasible for water points that are around 20 metres across, but only key points would need be fenced for the barrier to be effective, he said.