Inspire, the Eden and Razzett tal-Ħbiberija foundation, raised €110,607 during its annual televised fund-raising marathon.
The organisation said the funds would be used for educational and therapeutic services, which help "more than 1,000 children and adults with different abilities".
Inspire's CEO Nathan Farrugia said the event was more than a fund-raising exercise, highlighting the event's role as an outreach to society by showing how the funds were used.