The Prime Minister left for New York yesterday where he will be addressing the UN General Assembly on Thursday.
Along with Foreign Minister Tonio Borg he is accompanied by Nationalist backbencher Franco Debono.
Dr Gonzi will hold meetings with several leaders and will attend the UN Leadership Forum On Climate Change.
He will also inaugurate the EC New York English Language School, which is a Maltese investment.
The delegation later travels to San Francisco for meetings with the Maltese community and a visit to other Maltese businesses.
He is expected back on Monday.