Kenyan Pamela Jelimo claimed the Golden League's $1 million jackpot on Friday night, while fellow Olympic champion Usain Bolt beat Asafa Powell to win the 100 metres at the Memorial Van Damme meeting.
Croatian high jumper Blanka Vlasic missed out on a share of the jackpot after finishing second behind German Ariane Friedrich, but ahead of Olympic champion and home favourite Tia Hellebaut who surprisingly finished third.
The 18-year-old Jelimo won the 800 metres in one minute 55.16 seconds, more than three seconds ahead of compatriot Janeth Jepkosgei and third-placed Kenia Sinclair of Jamaica.
Earlier, Bolt powered past fellow Jamaican Powell in the 100 metres to set a new course record time of 9.77 seconds. Powell, who ran the joint second-fastest 100 of all time in Lausanne on Tuesday, finished in 9.83 after leading for most of the race until Bolt ran past him in the final 10 metres.
"I am used to chasing him," Bolt told reporters after a contest Powell described as "one of the most exciting ever. I was very excited about this race and knew it would be close".
Nesta Carter made it a Jamaican clean sweep by coming third in 10.07.
There was further heartbreak for Vlasic - pipped for the gold by Hellebaut at this year's Beijing Games - when she failed on her final jump at 2.02 metres.
Friedrich and Hellebaut also failed clear that height but the German won on the countback in one of the biggest shocks of the night having got over 1.97 on her first jump while Vlasic needed two attempts and Hellebaut three.
In the women's 100 metres, Belgium's European champion Kim Gevaert marked her last ever appearance on home soil when she scorched to victory in 11.25 seconds.
Amid the loudest roar of the night from the 50,000 capacity crowd, Debbie Ferguson of the Bahamas finished second and American Me'Lisa Barber was third behind the tearful 30 year-old Gevaert, who will retire at the end of the year.
Elsewhere, Russia's Olympic champion Yelena Isinbayeva won the pole vault with an unimpressive jump of 4.72 metres, blaming a combination of tiredness after Beijing and the damp weather.
American Jeremy Wariner overcame the wet and windy conditions to hold off Britain's Martyn Rooney to win the 400 metres in 44.44 seconds.
Kenya's Paul Koech stunned Olympic and world champion Brimin Kipruto to win the 3,000 metres steeplechase while Kenyan Olympic silver medallist Eliud Kipchoge easily won the 5,000 in the opening race of the night.
World champion Tero Pitkamaki, who finished third in China, gained revenge on Norway's Olympic champion Andreas Thorkildsen in the javelin, winning with a throw of 85.82 metres.
Thorkildsen finished third behind Latvia's Beijing silver medallist Ainars Kovals.