British Airways said that as from March 30 it will operate the daily service to London Gatwick which at present is handled by its franchisee partner GB Airways.
The route will be serviced by B737 airliners.
The full-service flights, which will include complimentary food and drinks, business and economy class cabins, leave Malta at 5.25 a.m. with the return flight departing Gatwick at 9.55 p.m.
James Stagno Navarra, British Airways manager for Malta said: "We have a long history of serving both business and leisure customers flying from Malta to London and we are confident that, with our full onboard service and low prices, this route will continue to be very popular".
Flights are available to book from today at www.ba.com.
GB Airways' franchise agreement with BA ends in March.
In October 2007, the British budget airline easyJet bought GB Airways for £103.5 million. EasyJet said on Wednesday it will be operating flights from Manchester and London Gatwick to Malta as from March 30.