Mqabba vs Pietà Hotspurs (today at 3 p.m., National Stadium).
Mqabba and Pietà Hotspurs, two teams who are expected to battle for Premier League survival this season, square up in the opening match of the weekend, weather-permitting.
The Hotspurs are boosted by the return to fitness of Bulgarian duo Rumen Galabov and Martin Deanov as coach Carmel Busuttil looks to field his strongest team in his bid to return Pieta to winning ways.
Mqabba will be hoping to maintain the progress shown in their recent matches as they bid to narrow the gap from their fellow relegation rivals.
Coach Joey Falzon is sweating over the fitness of Brazilian midfielder Fabio Silva who is struggling with a muscle strain while veteran Albert Busuttil has been down with flu.
Hibs vs Msida St Joseph (tomorrow at 3 p.m., National Stadium).
Hibs and Msida St Joseph will be chasing valuable points tomorrow as they look to strengthen their challenge for a Championship Pool berth.
Hibs have failed to carry their fine pre-season form into the Premier League and are currently sixth in the standings.
Coach Robert Gatt is urging his players to be more consistent in their performances, knowing that continuity is crucial for Hibs to rejoin the race for the Premier League title.
The Hibs coach has concerns about the fitness of Nigerian striker Ndubisi Chukunyere who has a knee injury while his compatriot Uzeh Edafe is also rated as doubtful.
Msida, on their part, have parted ways with Algerian striker Ouahchia Yacine and Nigerian defender George Ogbonna after they failed to leave the desired impression.
The Saints have already established contact with two Brazilian forwards who are expected to arrive next week. Coach Patrick Curmi is confident the new players will solve the team's attacking problems.
Sliema Wanderers vs Marsaxlokk (tomorrow at 5 p.m., National Stadium).
After their morale-boosting victory over Valletta, Sliema Wanderers are in for another stern test when they take on champions Marsaxlokk in the final match of the weekend.
Ray Farrugia, the Sliema coach, was pleased with his team's performance against Valletta and will be hoping for more improvement from his players as the Wanderers look to go into the six-week break well placed in the race for the title.
The Sliema coach must make do without left-back Ian Azzopardi who injured his ankle during Malta's 3-2 defeat to Moldova in midweek.
Marsaxlokk coach Brian Talbot is hampered by the absence of two key players for tomorrow's clash as Carlo Mamo and Malcolm Licari are out after both had a hernia operation.
The Marsaxlokk duo are expected to return to action in December.
Defender Charlò Magro is doubtful with a hamstring injury.
The English coach remarked that Marsaxlokk are the "underdogs" as they have nothing to lose against title favourites Sliema following the latter's spending spree in the summer.